Exploring shared genetics between maximal oxygen uptake and disease: the HUNT study-Reference-Cited by-同舟云学术

Exploring shared genetics between maximal oxygen uptake and disease: the HUNT study

Published:2023-10-01 Issue:10 Volume:55 Page:440-451
ISSN:1094-8341
Container-title:Physiological Genomics
language:en
Short-container-title:Physiological Genomics

Author:

Nordeidet Ada N.¹^ORCID,Klevjer Marie¹²,Wisløff Ulrik¹³,Langaas Mette⁴,Bye Anja¹²

Affiliation:

1. Department of Circulation and Medical Imaging, Cardiac Exercise Research Group, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway

2. Department of Cardiology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway

3. Centre for Research on Exercise, Physical Activity and Health, School of Human Movement and Nutrition Sciences, University of Queensland, Brisbane, Queensland, Australia

4. Department of Mathematical Sciences, Faculty of Information Technology and Electrical Engineering, Norwegian University of Science and Technology, Trondheim, Norway

Abstract

To our knowledge, this is the first genetic association study exploring how genes linked to cardiorespiratory fitness (CRF) relate to disease risk. By investigating shared genetics, we found indications that genetic variants linked to directly measured CRF also affect the level of blood creatinine, risk of diabetes, and endocarditis. Less certain findings showed that genetic variants of high CRF might cause lower body mass index, healthier HDL cholesterol, and lower resting heart rate.

Funder

NTNU | Senter for Autonome Marine Operasjoner og Systemer

HHS | National Institutes of Health

Helse Midt-Norge

Norges Forskningsråd

UM | Medical School, University of Michigan

Publisher

American Physiological Society

Subject

Genetics,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/physiolgenomics.00026.2023

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