Affiliation:
1. Department of Pharmacology and Physiology, Saint Louis University School of Medicine, St. Louis, Missouri
Abstract
Adropin, a recently described peptide hormone produced in the brain and liver, has been reported to have physiologically relevant actions on glucose homeostasis and lipogenesis, and to exert significant effect on endothelial function. We describe a central nervous system action of adropin to inhibit water drinking and identify a potential adropin receptor, the orphan G protein-coupled receptor, GPR19. Reduction in GPR19 mRNA levels in medial basal hypothalamus of male rats resulted in the loss of the inhibitory effect of adropin on water deprivation-induced thirst. The identification of a novel brain action of adropin and a candidate receptor for the peptide should extend and accelerate the study of the potential therapeutic value of adropin or its mimetics for the treatment of metabolic disorders.
Funder
HHS | NIH | National Heart, Lung, and Blood Institute (NHBLI)
HHS | NIH | National Institute of General Medical Sciences (NIGMS)
Publisher
American Physiological Society
Subject
Physiology (medical),Physiology
Cited by
80 articles.
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