The scavenger endothelial cell: a new player in homeostasis and immunity

Author:

Sørensen Karen Kristine1,McCourt Peter1,Berg Trond2,Crossley Clive3,Couteur David Le4,Wake Kenjiro56,Smedsrød Bård1

Affiliation:

1. Vascular Biology Research Group, Department of Medical Biology, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway;

2. Department of Biology, University of Oslo, Blindern, Oslo, Norway;

3. Institute for Marine and Antarctic Studies, University of Tasmania, Hobart, Tasmania, Australia;

4. Centre for Education and Research on Ageing and the ANZAC Research Institute, Concord Repatriation General Hospital and the University of Sydney, Sydney, New South Wales, Australia;

5. Tokyo Medical and Dental University and Liver Research Unit, Tokyo, Japan; and

6. Minophagen Pharmaceutical Company Limited, Tokyo, Japan

Abstract

To maintain homeostasis, the animal body is equipped with a powerful system to remove circulating waste.1This review presents evidence that the scavenger endothelial cell (SEC) is responsible for the clearance of blood-borne waste macromolecules in vertebrates. SECs express pattern-recognition endocytosis receptors (mannose and scavenger receptors), and in mammals, the endocytic Fc gamma-receptor IIb2. This cell type has an endocytic machinery capable of super-efficient uptake and degradation of physiological and foreign waste material, including all major classes of biological macromolecules. In terrestrial vertebrates, most SECs line the wall of the liver sinusoid. In phylogenetically older vertebrates, SECs reside instead in heart, kidney, or gills. SECs, thus, by virtue of their efficient nonphagocytic elimination of physiological and microbial substances, play a critical role in the innate immunity of vertebrates. In major invertebrate phyla, including insects, the same function is carried out by nephrocytes. The concept of a dual-cell principle of waste clearance is introduced to emphasize that professional phagocytes (macrophages in vertebrates; hemocytes in invertebrates) eliminate larger particles (>0.5 μm) by phagocytosis, whereas soluble macromolecules and smaller particles are eliminated efficiently and preferentially by clathrin-mediated endocytosis in nonphagocytic SECs in vertebrates or nephrocytes in invertebrates. Including these cells as important players in immunology and physiology provides an additional basis for understanding host defense and tissue homeostasis.

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

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