Micropuncture: unlocking the secrets of renal function

Author:

Sands Jeff M.

Abstract

This essay looks at the historical significance of five APS classic papers that are freely available online: Wearn JT and Richards AN. Observations on the composition of glomerular urine, with particular reference to the problem of reabsorption in the renal tubules. Am J Physiol 71: 209—227, 1924 ( http://ajplegacy.physiology.org/cgi/reprint/71/1/209 ). Richards AN and Walker AM. Methods of collecting fluid from known regions of the renal tubules of Amphibia and of perfusing the lumen of a single tubule. Am J Physiol 118: 111—120, 1936 ( http://ajplegacy.physiology.org/cgi/reprint/118/1/111 ). Walker AM and Hudson CL. The reabsorption of glucose from the renal tubule in Amphibia and the action of phlorhizin upon it. Am J Physiol 118: 130—143, 1936 ( http://ajplegacy.physiology.org/cgi/reprint/118/1/130 ). Walker AM and Oliver J. Methods for the collection of fluid from single glomeruli and tubules of the mammalian kidney. Am J Physiol 134: 562—579, 1941 ( http://ajplegacy.physiology.org/cgi/reprint/134/3/562 ). Walker AM, Bott PA, Oliver J, and MacDowell MC. The collection and analysis of fluid from single nephrons of the mammalian kidney. Am J Physiol 134: 580—595, 1941 ( http://ajplegacy.physiology.org/cgi/reprint/134/3/580 ).

Publisher

American Physiological Society

Subject

Physiology

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