Metabolic syndrome-associated murine aortic wall stiffening is associated with premature elastic fibers aging-Reference-Cited by-同舟云学术

Metabolic syndrome-associated murine aortic wall stiffening is associated with premature elastic fibers aging

Published:2024-09-01 Issue:3 Volume:327 Page:C698-C715
ISSN:0363-6143
Container-title:American Journal of Physiology-Cell Physiology
language:en
Short-container-title:American Journal of Physiology-Cell Physiology

Author:

Vanalderwiert Laetitia¹,Henry Auberi¹,Wahart Amandine¹,Carvajal Berrio Daniel A.²,Brauchle Eva M.²³,El Kaakour Lara¹,Schenke-Layland Katja²³⁴^ORCID,Brinckmann Juergen⁵,Steenbock Heiko⁵,Debelle Laurent¹,Six Isabelle⁶,Faury Gilles⁷,Jaisson Stéphane¹⁸,Gillery Philippe¹⁸,Durlach Vincent¹⁹,Sartelet Hervé¹^ORCID,Maurice Pascal¹^ORCID,Bennasroune Amar¹^ORCID,Martiny Laurent¹^ORCID,Duca Laurent¹,Romier Béatrice¹^ORCID,Blaise Sébastien¹^ORCID

Affiliation:

1. UMR CNRS 7369 MEDyc, University of Reims Champagne-Ardenne, Reims, France

2. Department for Medical Technologies and Regenerative Medicine, Institute of Biomedical Engineering, Eberhard Karls University Tübingen, Tübingen, Germany

3. NMI Natural and Medical Sciences Institute, Reutlingen, Germany

4. Division of Cardiology, Department of Medicine/Cardiology, Cardiovascular Research Laboratories, David Geffen School of Medicine at UCLA, Los Angeles, California, United States

5. Institute of Virology and Cell Biology, University of Lübeck, Lübeck, Germany

6. Research Unit 7517, Pathophysiological Mechanisms and Consequences of Cardiovascular Calcifications (MP3CV), University of Picardie Jules Verne, Amiens, France

7. University Grenoble Alpes, INSERM, CHU Grenoble Alpes, Grenoble, France

8. Biochemistry Department, University Hospital of Reims, Reims, France

9. Cardiovascular and Thoracic Division, Hôpital Robert Debré, Reims, France

Abstract

Aortic elastic fibers of young (6-mo old) individuals with diabetes degrade prematurely and exhibit an appearance like that found in aged (20-mo old) nondiabetic mice. Exacerbated elastolysis and elastin-derived peptide production are characteristic elements, contributing to early aortic wall rigidity and hypertension development. Therefore, limiting this early aging could be a judicious therapeutic approach to reduce cardiovascular complications and premature death in patients with diabetes.

Funder

Conseil régional du Grand Est

EC | European Regional Development Fund

Université de Reims Champagne-Ardenne

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpcell.00615.2023

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