Senescence-associated alterations in the extracellular matrix: deciphering their role in the regulation of cellular function

Author:

Mavrogonatou Eleni1,Papadopoulou Adamantia1,Pratsinis Harris1,Kletsas Dimitris1ORCID

Affiliation:

1. Laboratory of Cell Proliferation and Ageing, Institute of Biosciences and Applications, National Centre for Scientific Research “Demokritos,” Athens, Greece

Abstract

The extracellular matrix (ECM) is a dynamic structural network that provides a physical scaffolding, as well as biochemical factors that maintain normal tissue homeostasis and thus its disruption is implicated in many pathological conditions. On the other hand, senescent cells express a particular secretory phenotype, affecting the composition and organization of the surrounding ECM and modulating their microenvironment. As accumulation of senescent cells may be linked to the manifestation of several age-related conditions, senescence-associated ECM alterations may serve as targets for novel anti-aging treatment modalities. Here, we will review characteristic changes in the ECM elicited by cellular senescence and we will discuss the complex interplay between ECM and senescent cells, in relation to normal aging and selected age-associated pathologies.

Funder

Operational Program “Competitiveness, Entrepreneurship and Innovation”

Publisher

American Physiological Society

Subject

Cell Biology,Physiology

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