The mechanosensitive gene <i>arrestin domain containing 2</i> regulates myotube diameter with direct implications for disuse atrophy with aging-Reference-Cited by-同舟云学术

The mechanosensitive gene arrestin domain containing 2 regulates myotube diameter with direct implications for disuse atrophy with aging

Published:2024-03-01 Issue:3 Volume:326 Page:C768-C783
ISSN:0363-6143
Container-title:American Journal of Physiology-Cell Physiology
language:en
Short-container-title:American Journal of Physiology-Cell Physiology

Author:

Laskin Grant R.¹^ORCID,Cabrera Ana Regina²^ORCID,Greene Nicholas P.²^ORCID,Tomko Robert J.³^ORCID,Vied Cynthia⁴,Gordon Bradley S.¹⁵^ORCID

Affiliation:

1. Department of of Health, Nutrition, and Food Sciences, Florida State University, Tallahassee, Florida, United States

2. Department of Health, Human Performance and Recreation, Cachexia Research Laboratory, Exercise Science Research Center, University of Arkansas, Fayetteville, Arkansas, United States

3. Department of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, Florida, United States

4. Translational Science Laboratory, Florida State University College of Medicine, Tallahassee, Florida, United States

5. Institute of Sports Sciences and Medicine, Florida State University, Tallahassee, Florida, United States

Abstract

We establish Arrdc2 as a novel mechanosensitive gene highly induced in response to mechanical unloading, particularly in aged muscle. Arrdc2 induction in C2C12 myotubes is sufficient to produce thinner myotubes and a transcriptional landscape consistent with muscle atrophy and disuse.

Funder

Institute of Successful Longevity at Florida State University

HHS | NIH | Office of Extramural Research

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpcell.00444.2023

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