Vessel-on-a-chip models for studying microvascular physiology, transport, and function in vitro

Author:

Moses Savannah R.1,Adorno Jonathan J.2,Palmer Andre F.1,Song Jonathan W.3

Affiliation:

1. Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH, United States

2. Department of Biomedical Engineering, The Ohio State University, Columbus, OH, United States

3. Department of Mechanical and Aerospace Engineering, The Ohio State University, Columbus, OH, USA; The Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA

Abstract

To understand how the microvasculature grows and remodels, researchers require reproducible systems that emulate the function of living tissue. Innovative contributions toward fulfilling this important need have been made by engineered microvessels assembled in vitro using microfabrication techniques. Microfabricated vessels, commonly referred to as "vessels on a chip," are from a class of cell culture technologies that uniquely integrate microscale flow phenomena, tissue-level biomolecular transport, cell-cell interactions, and proper 3-D extracellular matrix environments under well-defined culture conditions. Here, we discuss the enabling attributes of microfabricated vessels that make these models more physiological compared to established cell culture techniques, and the potential of these models for advancing microvascular research. This review highlights the key features of microvascular transport and physiology, critically discusses the strengths and limitations of different microfabrication strategies for studying the microvasculature, and provides a perspective on current challenges and future opportunities for vessel on a chip models.

Funder

American Heart Association

NSF | ENG | Division of Chemical, Bioengineering, Environmental, and Transport Systems

HHS | NIH | National Heart, Lung, and Blood Institute

The Mark Foundation for Cancer Research

U.S. Department of Defense

Publisher

American Physiological Society

Subject

Cell Biology,Physiology

Reference212 articles.

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