Emodin ameliorates doxorubicin-induced cardiotoxicity by inhibiting ferroptosis through the remodeling of gut microbiota composition-Reference-Cited by-同舟云学术

Emodin ameliorates doxorubicin-induced cardiotoxicity by inhibiting ferroptosis through the remodeling of gut microbiota composition

Published:2024-01-01 Issue:1 Volume:326 Page:C161-C176
ISSN:0363-6143
Container-title:American Journal of Physiology-Cell Physiology
language:en
Short-container-title:American Journal of Physiology-Cell Physiology

Author:

Hu Songqing¹²,Zhou Jiedong³,Hao Jinjin²,Zhong Zuoquan⁴,Wu Haowei²,Zhang Peipei⁵,Yang Juntao³,Guo Hangyuan³,Chi Jufang¹^ORCID

Affiliation:

1. Department of Cardiology, Zhuji People’s Hospital, Shaoxing, People’s Republic of China

2. School of Medicine, Zhejiang University, Hangzhou, People’s Republic of China

3. School of Medicine, Shaoxing University, Shaoxing, People’s Republic of China

4. The First Clinical Medical College, Wenzhou Medical University, Wenzhou, People’s Republic of China

5. Zhejiang Chinese Medical University, Hangzhou, People’s Republic of China

Abstract

This study demonstrated for the first time the protective effect of emodin against DIC and verified by FMT that its cardioprotective effect was achieved by remodeling gut microbiota composition, resulting in attenuation of ferroptosis. Furthermore, we demonstrated that these effects were mediated by the redox-related gene Nrf2.

Funder

MOST | National Natural Science Foundation of China

Publisher

American Physiological Society

Subject

Cell Biology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpcell.00477.2023

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