Aloperine protects pulmonary hypertension via triggering PPARγ signaling and inhibiting calcium regulatory pathway in pulmonary arterial smooth muscle cells-Reference-Cited by-同舟云学术

Aloperine protects pulmonary hypertension via triggering PPARγ signaling and inhibiting calcium regulatory pathway in pulmonary arterial smooth muscle cells

Published:2023-10-01 Issue:4 Volume:325 Page:C1058-C1072
ISSN:0363-6143
Container-title:American Journal of Physiology-Cell Physiology
language:en
Short-container-title:American Journal of Physiology-Cell Physiology

Author:

Shan Xiaoqian¹²^ORCID,Gegentuya ¹²³,Wang Jing⁴,Feng Huazhuo²,Zhang Zizhou²⁵,Zheng Qiuyu⁶,Zhang Qing¹,Yang Kai²^ORCID,Wang Jian²⁵,Xu Lei¹

Affiliation:

1. Department of Pulmonary and Critical Care Medicine, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China

2. State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China

3. Department of Pulmonary and Critical Care Medicine, Affiliated Hospital of Inner Mongolia Minzu University, Tongliao, China

4. Department of Scientific Research, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, China

5. Guangzhou National Laboratory, Guangzhou International Bio Island, Guangzhou, China

6. Department of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China

Abstract

Aloperine attenuates monocrotaline-induced pulmonary hypertension (MCT-PH) in rats by inhibiting the pulmonary vascular remodeling and proliferation of pulmonary arterial smooth muscle cells (PASMCs). In mechanism, Aloperine not only exerts a transient KCNQ-dependent vasodilation in precontracted pulmonary arteries (PAs) from both control and MCT-PH rats but also activates PPARγ nuclear translocation and signaling transduction in PASMCs, which chronically inhibits the calcium regulatory pathway and proliferation of PASMCs.

Funder

IMMU General Program

IMMU Graduate Education Teaching Reform Research Practice Project

IMMU Doctoral Starting Up Foundation

内蒙古自治区科学技术厅 | Natural Science Foundation of Inner Mongolia Autonomous Region

MOST | National Natural Science Foundation of China

Publisher

American Physiological Society

Subject

Cell Biology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpcell.00286.2023

Reference35 articles.

1. Calcium-Sensing Receptor Regulates Cytosolic [Ca2+] and Plays a Major Role in the Development of Pulmonary Hypertension

2. Epigenetic Regulation of Pulmonary Arterial Hypertension-Induced Vascular and Right Ventricular Remodeling: New Opportunities?

3. Soluble GC stimulators and activators: Past, present and future

4. KCNQ Potassium Channels as Targets of Botanical Folk Medicines

5. A Review on Recent Advances in Aloperine Research: Pharmacological Activities and Underlying Biological Mechanisms