CFTR expression in human salivary gland acinar cells-Reference-Cited by-同舟云学术

CFTR expression in human salivary gland acinar cells

Published:2024-03-01 Issue:3 Volume:326 Page:C742-C748
ISSN:0363-6143
Container-title:American Journal of Physiology-Cell Physiology
language:en
Short-container-title:American Journal of Physiology-Cell Physiology

Author:

Muñoz Manuel¹,Acevedo Alejandro¹,Ovitt Catherine E.²^ORCID,Luitje Martha E.³,Maruyama Eri O.²,Catalán Marcelo A.⁴^ORCID

Affiliation:

1. Instituto de Nutrición y Tecnología de los Alimentos, Universidad de Chile, Santiago, Chile

2. Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, New York, United States

3. Department of Otolaryngology, University of Rochester Medical Center, Rochester, New York, United States

4. Instituto de Fisiología, Facultad de Medicina, Universidad Austral de Chile, Valdivia, Chile

Abstract

This study addresses the uncertainty about the impact of CFTR on human salivary gland function. We found CFTR transcripts in a subset of duct cells known as ionocytes, as well as in acinar cells. Isolated human parotid acinar cells exhibited Cl− conductance consistent with CFTR activity. This marks the first documented evidence of functional CFTR expression in human salivary gland acinar cells.

Funder

HHS | NIH | National Institute of Dental and Craniofacial Research

MINEDUC | CONICYT | Fondo Nacional de Desarrollo Científico y Tecnológico

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpcell.00549.2023

Reference42 articles.

1. Regulation of electrolyte and fluid secretion in salivary acinar cells

2. A fluid secretion pathway unmasked by acinar-specific Tmem16A gene ablation in the adult mouse salivary gland

3. Ae4 (Slc4a9) Anion Exchanger Drives Cl− Uptake-dependent Fluid Secretion by Mouse Submandibular Gland Acinar Cells

4. Ussing's Two-Membrane Hypothesis: The Model and Half a Century of Progress

5. Tmem16A Encodes the Ca2+-activated Cl− Channel in Mouse Submandibular Salivary Gland Acinar Cells

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