Glycolytic enzyme PFKFB3 regulates sphingosine 1-phosphate receptor 1 in proangiogenic glomerular endothelial cells under diabetic condition-Reference-Cited by-同舟云学术

Glycolytic enzyme PFKFB3 regulates sphingosine 1-phosphate receptor 1 in proangiogenic glomerular endothelial cells under diabetic condition

Published:2023-11-01 Issue:5 Volume:325 Page:C1354-C1368
ISSN:0363-6143
Container-title:American Journal of Physiology-Cell Physiology
language:en
Short-container-title:American Journal of Physiology-Cell Physiology

Author:

Yu Baixue¹²,Shen Kaiyuan³,Li Tingting¹²,Li Jiawei²⁴,Meng Mei¹²,Liu Wenjie¹²,Tang Qunye²⁴,Zhu Tongyu²⁴,Wang Xin³^ORCID,Leung Susan W. S.⁵^ORCID,Shi Yi¹²^ORCID

Affiliation:

1. Institute of Clinical Science, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of China

2. Key Laboratory of Organ Transplantation, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of China

3. Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of China

4. Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of China

5. Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People’s Republic of China

Abstract

Proangiogenetic glomerular endothelial cells (GECs) are activated in diabetic nephropathy. High glucose upregulates glycolytic enzyme phosphofructokinase/fructose bisphosphatase 3 (PFKFB3) in proangiogenetic cells. PFKFB3 protects the glomerular filtration barrier by targeting endothelial S1pR1. MiRNA-590-3p restores endothelial cell function and mitigates diabetic nephropathy.

Funder

Zheng-YI Scholar Scientific Research Project of Fudan University

The Dual First-Class Initiation Fudan University

The Nature Science Foundation of Shanghai

Publisher

American Physiological Society

Subject

Cell Biology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpcell.00261.2023

Reference59 articles.

1. Association Between Diabetes and Cause-Specific Mortality in Rural and Urban Areas of China

2. Amelioration of Diabetic Nephropathy Using a Retinoic Acid Receptor β2 Agonist

3. Podocyte detachment and reduced glomerular capillary endothelial fenestration promote kidney disease in type 2 diabetic nephropathy

4. The single-cell transcriptomic landscape of early human diabetic nephropathy

5. Single-Cell RNA Profiling of Glomerular Cells Shows Dynamic Changes in Experimental Diabetic Kidney Disease