Role of glucuronidated 25-hydroxyvitamin D on colon gene expression in mice-Reference-Cited by-同舟云学术

Role of glucuronidated 25-hydroxyvitamin D on colon gene expression in mice

Published:2020-08-01 Issue:2 Volume:319 Page:G253-G260
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Reynolds Carmen J.¹,Koszewski Nicholas J.²,Horst Ronald L.³,Beitz Donald C.¹,Goff Jesse P.²

Affiliation:

1. Department of Animal Science, Iowa State University, Ames, Iowa

2. Department of Biomedical Sciences, Iowa State University, Ames, Iowa

3. Heartland Assays, Ames, Iowa

Abstract

We found that 25OHD-Gluc, an endogenously produced metabolite, is delivered to the colon via bile to induce vitamin D-mediated responses in the colon.

Funder

HHS | NIH | National Cancer Institute

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00355.2019

Reference43 articles.

1. 25-Hydroxyvitamin D3: Evidence of an Enterohepatic Circulation in Man

2. Conjugated forms of [3H]1α,25-dihydroxyvitamin D3 in rat bile

3. 25-Hydroxyvitamin D3-1α-hydroxylase Expression in Normal and Malignant Human Colon