Affiliation:
1. Division of Nutritional Sciences, Cornell University, Ithaca, New York, United States
Abstract
Metal dyshomeostasis, intestinal permeability, and gut dysbiosis are emerging signatures of chronic disorders, including inflammatory bowel diseases, type-2 diabetes, and obesity. Studies in reciprocal regulations between host intestinal metal transporters genes and gut microbiome are scarce. Our research revealed a potential predisease microbial susceptibility state dependent on the host metal transporter gene, Slc39a14/Zip14, that contributes to intestinal permeability providing new insight into understanding host metal transporter gene-microbiome interactions in developing chronic disease.
Funder
HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases
Cornell University
HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases
Publisher
American Physiological Society
Subject
Physiology (medical),Gastroenterology,Hepatology,Physiology
Cited by
1 articles.
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