Lipophilic statins inhibit YAP coactivator transcriptional activity in HCC cells through Rho-mediated modulation of actin cytoskeleton-Reference-Cited by-同舟云学术

Lipophilic statins inhibit YAP coactivator transcriptional activity in HCC cells through Rho-mediated modulation of actin cytoskeleton

Published:2023-09-01 Issue:3 Volume:325 Page:G239-G250
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Benhammou Jihane N.¹²³^ORCID,Qiao Bo¹²,Ko Arthur⁴,Sinnett-Smith James¹²^ORCID,Pisegna Joseph R.¹²³,Rozengurt Enrique¹²³^ORCID

Affiliation:

1. Vatche and Tamar Manoukian Division of Digestive Diseases, University of California, Los Angeles, California, United States

2. Division of Gastroenterology, Hepatology and Parental Nutrition, Veteran Affairs Greater Los Angeles Healthcare System, Los Angeles, California, United States

3. Jonsson Comprehensive Cancer Center, University of California, Los Angeles, California, United States

4. Center for Genetic Medicine Research, Childrens National Research Institute, Washington, District of Columbia, United States

Abstract

Statins are widely used for the treatment of cardiovascular diseases. Recently, their use has been associated with a decrease in the incidence of hepatocellular carcinoma (HCC); however, their mechanism(s) has remained elusive. In this study, we delineate the mechanism by which statins affect the Yes-associated protein (YAP), which has emerged as a key oncogenic pathway in HCC. We investigate each step of the mevalonate pathway and demonstrate that statins regulate YAP via Rho GTPases.

Funder

Foundation for the National Institutes of Health

HHS | NIH | National Center for Advancing Translational Sciences

U.S. Department of Veterans Affairs

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00089.2023

Reference39 articles.

1. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries

2. HCC surveillance improves early detection, curative treatment receipt, and survival in patients with cirrhosis: A meta-analysis

3. Use of Hepatocellular Carcinoma Surveillance in Patients With Cirrhosis: A Systematic Review and Meta‐Analysis

4. DETECT: Development of Technologies for Early HCC Detection

5. A Telephone and Mail Outreach Program Successfully Increases Uptake of Hepatocellular Carcinoma Surveillance