Effect of Toll-like receptor-2, -4, -5, -7, and NOD2 stimulation on potassium channel conductance in intestinal epithelial cells-Reference-Cited by-同舟云学术

Effect of Toll-like receptor-2, -4, -5, -7, and NOD2 stimulation on potassium channel conductance in intestinal epithelial cells

Published:2022-11-01 Issue:5 Volume:323 Page:G410-G419
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Cosme Dina¹²^ORCID,Soares-da-Silva Patrício¹²,Magro Fernando¹³⁴⁵⁶^ORCID

Affiliation:

1. Unit of Pharmacology and Therapeutics, Department of Biomedicine, Faculty of Medicine, University of Porto, Porto, Portugal

2. MedInUP, Center for Drug Discovery and Innovative Medicines, Porto, Portugal

3. Department of Gastroenterology, São João Hospital University Centre, Porto, Portugal

4. Center for Health Technology and Services Research, Porto, Portugal

5. Clinical Pharmacology Unit, São João Hospital University Centre, Porto, Portugal

6. Portuguese Inflammatory Bowel Disease Group, Porto, Portugal

Abstract

This study highlights that PRRs stimulation directly influences K+-channel conductance in IECs. TLR-2, -4, -7 stimulation decreased K+ conductance, whereas TLR5 and NOD2 stimulation had the opposite effect, leading to an increase of it instead. This study reports for the first time that KCa3.1- and Kir6-channels play a role in K+ transport pathways triggered by TLR4 stimulation. These findings suggest that KCa3.1- and Kir6-channels modulation may be a potential target for new therapeutic agents in IBD.

Funder

Portuguese Inflammatory Bowel Disease Group

MEC | Fundação para a Ciência e a Tecnologia

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00139.2022

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1. Corrigendum for Cosme et al., volume 323, 2022, p. G410–G419;American Journal of Physiology-Gastrointestinal and Liver Physiology;2023-01-01