The effects of simulated gastroesophageal reflux on infant pig oropharyngeal feeding physiology

Author:

Edmonds Chloe E.12ORCID,Robbins Kaitlyn N.13,Dvorak Elizabeth G.14,Howe Stephen P.1,Sheldon Sarah A.1,Mayerl Christopher J.5,Owairu Brianna A.1,Young Brady M.1,German Rebecca Z.12ORCID

Affiliation:

1. Department of Anatomy and Neurobiology, Northeast Ohio Medical University, Rootstown, Ohio, United States

2. School of Biomedical Sciences, Kent State University, Kent, Ohio, United States

3. School of Speech-Language Pathology and Audiology, The University of Akron, Akron, Ohio, United States

4. Department of Biology, The University of Akron, Akron, Ohio, United States

5. Department of Biological Sciences, Northern Arizona University, Flagstaff, Arizona, United States

Abstract

Simulated gastroesophageal reflux (GER) in an infant pig model resulted in significant changes in pharyngeal swallowing, which suggests that esophageal afferents are centrally integrated to alter motor outputs to the pharynx. In addition, decreased swallow frequency and increased bolus sizes may be underlying mechanisms by which esophageal pathologies induce oropharyngeal dysphagia. The infant pig model used here allows for a mechanistic approach, which can facilitate the design of intervention strategies based on neurophysiology.

Funder

HHS | National Institutes of Health

Publisher

American Physiological Society

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