The bHLH transcription factor ASCL1 promotes differentiation of endocrine cells in the stomach and is regulated by Notch signaling-Reference-Cited by-同舟云学术

The bHLH transcription factor ASCL1 promotes differentiation of endocrine cells in the stomach and is regulated by Notch signaling

Published:2023-11-01 Issue:5 Volume:325 Page:G458-G470
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Hibdon Elise S.¹,Keeley Theresa M.¹,Merchant Juanita L.²,Samuelson Linda C.¹³^ORCID

Affiliation:

1. Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States

2. Department of Medicine, University of Arizona, Tucson, Arizona, United States

3. Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States

Abstract

Although Notch signaling is known to regulate cellular differentiation in the stomach, downstream effectors are poorly described. Here we demonstrate that the bHLH transcription factor ASCL1 is expressed in endocrine cells in the stomach and is required for formation of neurogenin-3-dependent enteroendocrine cells but not enterochromaffin-like cells. We also demonstrate that Ascl1 expression is inhibited by Notch signaling, suggesting that ASCL1 is a Notch-regulated transcriptional effector directing enteroendocrine cell fate in the mouse stomach.

Funder

HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00043.2023

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