Volumetric graft changes after liver transplantation: evidence of adaptation to recipient body size

Author:

Arslan Alin1ORCID,Romano Antonio1,Wang Qiang23,Wang Benny1,Brismar Torkel B.23,Nowak Greg1

Affiliation:

1. Division of Transplantation Surgery, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden

2. Division of Medical Imaging and Technology, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden

3. Department of Radiology, Karolinska University Hospital Huddinge, Stockholm, Sweden

Abstract

This is the first and largest human study to verify the hypothesis that whole liver grafts adjust their size to match recipient body size 1 year after transplantation—a phenomenon that has previously only been observed in experimental animal studies and human case reports. The direction of volumetric changes is driven by the disparity between graft size relative to recipient body surface area and weight, as well as the intraoperative portal- and arterial graft perfusion.

Funder

Research grant from Stockholm County

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

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