Metabolomics analysis of urine from patients with alcohol-associated liver disease reveals dysregulated caffeine metabolism-Reference-Cited by-同舟云学术

Metabolomics analysis of urine from patients with alcohol-associated liver disease reveals dysregulated caffeine metabolism

Published:2023-02-01 Issue:2 Volume:324 Page:G142-G154
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Xu Raobo¹²³⁴,He Liqing¹²³⁴,Vatsalya Vatsalya²⁵,Ma Xipeng¹²³⁴,Kim Seongho⁶⁷,Mueller Eugene G.¹,Feng Wenke²³⁵⁸,McClain Craig J.²³⁵⁸⁹,Zhang Xiang¹²³⁴⁸^ORCID

Affiliation:

1. Department of Chemistry, University of Louisville, Louisville, Kentucky

2. Alcohol Research Center, University of Louisville School of Medicine, Louisville, Kentucky

3. Hepatobiology and Toxicology Center of Biomedical Research Excellence, University of Louisville School of Medicine Louisville, Louisville, Kentucky

4. Center for Regulatory and Environmental Analytical Metabolomics, University of Louisville, Louisville, Kentucky

5. Department of Medicine, University of Louisville, Louisville, Kentucky

6. Department of Oncology, Wayne State University, Detroit, Michigan

7. Biostatistics and Bioinformatics Core, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan

8. Department of Pharmacology and Toxicology, University of Louisville, Louisville, Kentucky

9. Robley Rex Louisville Veterans Affairs Medical Center, Louisville, Kentucky

Abstract

Our study using both untargeted and targeted metabolomics reveals the caffeine metabolic pathway is dysregulated in ALD. Three caffeine metabolites, 1-methylxanthine, paraxanthine, and 5-acetylamino-6-amino-3-methyluracil, can differentiate the severity of early-stage ALD.

Funder

HHS | NIH | NIH Office of the Director

HHS | NIH | National Institute of General Medical Sciences

HHS | NIH | National Institute on Alcohol Abuse and Alcoholism

U.S. Department of Veterans Affairs

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00228.2022

Reference47 articles.