Localized bioelectrical conduction block from radiofrequency gastric ablation persists after healing: safety and feasibility in a recovery model-Reference-Cited by-同舟云学术

Localized bioelectrical conduction block from radiofrequency gastric ablation persists after healing: safety and feasibility in a recovery model

Published:2022-12-01 Issue:6 Volume:323 Page:G640-G652
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Aghababaie Zahra¹,O’Grady Gregory¹²,Nisbet Linley A.¹,Modesto Andre E.²,Chan Chih-Hsiang Alexander¹^ORCID,Matthee Ashton¹,Amirapu Satya³,Beyder Arthur⁴,Farrugia Gianrico⁴^ORCID,Asirvatham Samuel J.⁵,Sands Gregory B.¹^ORCID,Paskaranandavadivel Niranchan¹^ORCID,Cheng Leo K.¹⁶^ORCID,Angeli-Gordon Timothy R.¹²^ORCID

Affiliation:

1. Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand

2. Department of Surgery, University of Auckland, Auckland, New Zealand

3. Histology Laboratory, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand

4. Division of Gastroenterology and Hepatology, and Enteric Neurosciences Program, Mayo Clinic, Rochester, Minnesota

5. Division of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota

6. Department of Surgery, Vanderbilt University, Nashville, Tennessee

Abstract

Ablation has recently emerged as a tool for modulating gastric electrical activation and may hold interventional potential for disorders of gastric function. However, previous studies have been limited to the acute intraoperative setting. This study now presents the safety of gastric ablation after postsurgical recovery and healing. Localized electrical conduction blocks created by ablation remained after 2 wk of healing, and no perforation or other complications were observed over the postsurgical period.

Funder

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

HHS | NIH | NIH Office of the Director

Manatu Hauora | Health Research Council of New Zealand

Royal Society Te Apārangi

Royal Society of New Zealand | Marsden Fund

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00116.2022