Disruption of hypoxia-inducible factor-2α in neutrophils decreases colitis-associated colon cancer-Reference-Cited by-同舟云学术

Disruption of hypoxia-inducible factor-2α in neutrophils decreases colitis-associated colon cancer

Published:2024-01-01 Issue:1 Volume:326 Page:G53-G66
ISSN:0193-1857
Container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology
language:en
Short-container-title:American Journal of Physiology-Gastrointestinal and Liver Physiology

Author:

Singhal Rashi¹^ORCID,Kotla Nikhil Kumar¹,Solanki Sumeet¹,Huang Wesley¹²,Bell Hannah N.¹,El-Derany Marwa O.¹³,Castillo Cristina¹,Shah Yatrik M.¹⁴⁵^ORCID

Affiliation:

1. Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States

2. Cellular and Molecular Biology and Medical Scientist Training Program, University of Michigan, Ann Arbor, Michigan, United States

3. Department of Biochemistry, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt

4. Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan, United States

5. Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States

Abstract

Despite the importance of hypoxia and neutrophils in colorectal cancer (CRC), the contribution of neutrophil-specific HIFs to colon tumorigenesis is not known. We describe that neutrophil HIF-1α has no impact on colon cancer, whereas neutrophil HIF-2α loss reduces CRC growth by decreasing proinflammatory and immunosuppressive cytokines. Furthermore, neutrophil HIF-2α does not reduce preestablished tumor growth or inflammation-induced colitis. The present study offers novel potential of neutrophil HIF-2α as a therapeutic target in CRC.

Funder

American Heart Association

American Physiological Society

Crohn's and Colitis Foundation

HHS | NIH | National Cancer Institute

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00182.2023

Reference70 articles.

1. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries

2. Global burden of colorectal cancer in 2020 and 2040: incidence and mortality estimates from GLOBOCAN

3. Colorectal cancer in inflammatory bowel disease: The risk, pathogenesis, prevention and diagnosis

4. Inflammation and Colon Cancer

5. Carcinogenesis in IBD: potential targets for the prevention of colorectal cancer