The effect of acute and 14-day exogenous ketone supplementation on glycemic control in adults with type 2 diabetes: two randomized controlled trials-Reference-Cited by-同舟云学术

The effect of acute and 14-day exogenous ketone supplementation on glycemic control in adults with type 2 diabetes: two randomized controlled trials

Published:2024-01-01 Issue:1 Volume:326 Page:E61-E72
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Falkenhain Kaja¹^ORCID,Oliveira Barbara F.¹,Islam Hashim¹^ORCID,Neudorf Helena¹^ORCID,Cen Haoning H.²,Johnson James D.²^ORCID,Madden Kenneth³,Singer Joel⁴,Walsh Jeremy J.⁵^ORCID,Little Jonathan P.¹^ORCID

Affiliation:

1. Faculty of Health and Social Development, School of Health and Exercise Sciences, University of British Columbia, Kelowna, British Columbia, Canada

2. Department of Cellular & Physiological Sciences, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada

3. Department of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada

4. Faculty of Medicine, School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada

5. Department of Kinesiology, Faculty of Science, McMaster University, Hamilton, Ontario, Canada

Abstract

Exogenous ketone supplements can acutely lower blood glucose, suggesting therapeutic potential in individuals with impaired glucose metabolism. However, the effect of exogenous ketones on glucose metabolism in adults with type 2 diabetes has not been investigated in a controlled setting. In adults with type 2 diabetes, ketone monoester ingestion did not lower blood glucose acutely in a fasted state and did not improve glycemic control across thrice daily premeal ingestion across 14 days.

Funder

Killam Accelerator Research Fellowship

Gouvernement du Canada | Canadian Institutes of Health Research

Michael Smith Foundation for Health Research

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00332.2023

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