PERK/ATF4-dependent expression of the stress response protein REDD1 promotes proinflammatory cytokine expression in the heart of obese mice-Reference-Cited by-同舟云学术

PERK/ATF4-dependent expression of the stress response protein REDD1 promotes proinflammatory cytokine expression in the heart of obese mice

Published:2023-01-01 Issue:1 Volume:324 Page:E62-E72
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Stevens Shaunaci A.¹,Gonzalez Aguiar Maria K.¹,Toro Allyson L.¹,Yerlikaya Esma I.¹,Sunilkumar Siddharth¹,VanCleave Ashley M.¹,Pfleger Jessica²,Bradley Elisa A.¹³,Kimball Scot R.¹^ORCID,Dennis Michael D.¹^ORCID

Affiliation:

1. Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, Pennsylvania

2. Fralin Biomedical Research Institute, Virginia Tech, Roanoke, Virginia

3. Division of Cardiovascular Medicine, Penn State Health Heart and Vascular Institute, Hershey S. Milton Medical Center, Hershey, Pennsylvania

Abstract

Interplay between endoplasmic reticulum stress and inflammation contributes to cardiovascular disease progression. The studies here identify the stress response protein known as REDD1 as a missing molecular link that connects the development of endoplasmic reticulum stress with increased production of proinflammatory cytokines in the hearts of obese mice.

Funder

American Heart Association

HHS | NIH | National Eye Institute

HHS | NIH | National Heart, Lung, and Blood Institute

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00238.2022

Reference50 articles.