High levels of uric acid inhibit BAT thermogenic capacity through regulation of AMPK-Reference-Cited by-同舟云学术

High levels of uric acid inhibit BAT thermogenic capacity through regulation of AMPK

Published:2023-10-01 Issue:4 Volume:325 Page:E376-E389
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Dong Meijuan¹^ORCID,An Kun²^ORCID,Mao Li¹^ORCID

Affiliation:

1. Department of Endocrinology, The Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University, Huaian, China

2. Department of Neurology, The Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University, Huaian, China

Abstract

To investigate the effect and mechanism of UA on BAT thermogenic capacity, we established HUA models in vitro and in vivo, and performed RNA sequencing analysis. Our results revealed that HUA suppresses mitochondrial biogenesis by regulating AMPK, thereby inhibiting BAT thermogenic capacity. Taken together, our study identifies UA as a novel regulator of BAT thermogenic capacity, providing a new strategy to combat obesity.

Funder

JST | Jiangsu Natural Science Foundation | Basic Research Program of Jiangsu Province

Nanjing Medical University

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00092.2023

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