Human liver afferent and efferent nerves revealed by 3-D/Airyscan super-resolution imaging-Reference-Cited by-同舟云学术

Human liver afferent and efferent nerves revealed by 3-D/Airyscan super-resolution imaging

Published:2024-02-01 Issue:2 Volume:326 Page:E107-E123
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Chen Chien-Chia¹^ORCID,Peng Shih-Jung²³,Chou Ya-Hsien²³,Lee Chih-Yuan¹,Lee Po-Huang¹⁴,Hu Rey-Heng¹⁵,Ho Ming-Chih¹⁶^ORCID,Chung Mei-Hsin³⁷,Hsiao Fu-Ting³,Tien Yu-Wen¹,Tang Shiue-Cheng²³^ORCID

Affiliation:

1. Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan

2. Department of Medical Science, National Tsing Hua University, Hsinchu, Taiwan

3. Institute of Biotechnology, National Tsing Hua University, Hsinchu, Taiwan

4. Department of Surgery, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan

5. Department of Surgery, National Taiwan University Hospital-Yunlin Branch, Yunlin, Taiwan

6. Department of Surgery, National Taiwan University Hospital-Hsinchu Branch, Hsinchu, Taiwan

7. Department of Pathology, National Taiwan University Hospital-Hsinchu Branch, Hsinchu, Taiwan

Abstract

We embed the human liver (vs. pancreas, positive control) in the high-refractive-index polymer for tissue clearing and antifade 3-D/Airyscan super-resolution neurohistology. The pancreas-liver comparison reveals: 1) sensory nerves in the hepatoportal space; 2) intralobular sympathetic innervation, including the nerve fibers and varicosities contacting the ballooning hepatocytes; and 3) parasympathetic innervation of the septal bile duct. Our results highlight the sensitivity and resolving power of 3-D/Airyscan super-resolution imaging in human liver neurohistology.

Funder

Ministry of Science and Technology, Taiwan

National Health Research Institutes

National Taiwan University Hospital

National Tsing Hua University

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00205.2023

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