3,6′-Disinapoyl sucrose alleviates cognitive deficits in APP/PS1 transgenic mice-Reference-Cited by-同舟云学术

3,6′-Disinapoyl sucrose alleviates cognitive deficits in APP/PS1 transgenic mice

Published:2023-11-01 Issue:5 Volume:130 Page:1174-1182
ISSN:0022-3077
Container-title:Journal of Neurophysiology
language:en
Short-container-title:Journal of Neurophysiology

Author:

Yuan Jiaqi¹,He Mengjie¹,Dai Xueling¹,Huo Qing¹,Chang Ping¹,Zhang Jing¹,Wang Shuo²,Sun Yaxuan¹^ORCID

Affiliation:

1. Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing, China

2. Tianjin Key Laboratory of Food Science and Health, School of Medicine, Nankai University, Tianjin, China

Abstract

In this study, for the first time, DISS was used in APP/PS1 transgenic mice to explore its neuroprotective effect. After gavage DISS for 1 mo, the impairment of learning and spatial memory ability and the loss of neurons in APP/PS1 mice were alleviated. DISS reduced a neuroprotective effect in AD mice via decreasing neuronal apoptosis, enhancing the expressions of CREB phosphorylation and BDNF, pointing to DISS as a new therapeutic target for AD.

Funder

academic research projects of Beijing Union University

MOST | National Natural Science Foundation of China

Publisher

American Physiological Society

Subject

Physiology,General Neuroscience

Link

https://journals.physiology.org/doi/pdf/10.1152/jn.00067.2023

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