Affiliation:
1. Division of Pediatric Neurology, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States
Abstract
Inhibition of glycolysis with 2-deoxyglucose (2-DG) represents a novel metabolic antiseizure approach, yet the mechanisms remain elusive. Here, we show that 2-DG’s antiseizure action is both glycolysis and temperature dependent but not mediated by the vacuole ATP pump (V-ATPase) or ATP-sensitive K+ channel (KATP). Our data provide new insights to understand 2-DG’s cellular mechanisms of action and, more broadly, neuronal metabolism and excitability.
Funder
Paine Foundation
Sandra and Malcolm Berman Foundation
Community Foundation of Southern Wisconsin
Publisher
American Physiological Society
Cited by
2 articles.
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