Preterm ovine respiratory epithelial cell responses to mechanical ventilation, lipopolysaccharide, and interleukin-13

Author:

Abugisisa Leenah1,Royse Emily X.1,Kemp Matthew W.2345,Jobe Alan H.246ORCID,Hillman Noah H.1ORCID

Affiliation:

1. Division of Neonatology, SSM Health Cardinal Glennon Children’s Hospital, Saint Louis University, St. Louis, Missouri, United States

2. Division of Obstetrics and Gynaecology, University of Western Australia, Perth, Western Australia, Australia

3. Center for Perinatal and Neonatal Medicine, Tohoku University Hospital, Sendai, Japan

4. School of Veterinary and Life Sciences, Murdoch University, Perth, Western Australia, Australia

5. Department of Obstetrics and Gynaecology, National University of Singapore, Singapore

6. Division of Pulmonary Biology, Cincinnati Children’s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, United States

Abstract

Preterm lamb respiratory epithelial cells can be extracted from the trachea and bronchi and frozen, and the preterm cells can respond in culture to stimulation with LPS or IL-13. Brief mechanical ventilation changes the distribution and cell type of preterm respiratory cells toward an adult phenotype, and mechanical ventilation alters the response to LPS in culture. Bronchoalveolar lavage fluid from preterm lambs receiving mechanical ventilation also alters unventilated preterm and adult responses to LPS.

Funder

Fleur-de-Lis Foundation

HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development

Publisher

American Physiological Society

Subject

Cell Biology,Physiology (medical),Pulmonary and Respiratory Medicine,Physiology

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