Effect of estrogen receptor α on cardiopulmonary adaptation to chronic developmental hypoxia in a rat model-Reference-Cited by-同舟云学术

Effect of estrogen receptor α on cardiopulmonary adaptation to chronic developmental hypoxia in a rat model

Published:2024-06-01 Issue:6 Volume:326 Page:L786-L795
ISSN:1040-0605
Container-title:American Journal of Physiology-Lung Cellular and Molecular Physiology
language:en
Short-container-title:American Journal of Physiology-Lung Cellular and Molecular Physiology

Author:

Severyn Nicholas T.¹^ORCID,Esparza Patricia²,Gao Huanling²,Mickler Elizabeth A.³,Albrecht Marjorie E.³,Fisher Amanda J.³,Yakubov Bahktiyor³,Cook Todd G.³,Slaven James E.²,Walts Avram D.⁴,Tepper Robert S.²,Lahm Tim⁴⁵⁶^ORCID

Affiliation:

1. Division of Neonatal-Perinatal Medicine, Department of Pediatrics, University of Kentucky School of Medicine, Lexington, Kentucky, United States

2. Division of Pulmonology, Department of Pediatrics, Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana, United States

3. Division of Pulmonology and Sleep Medicine, Indiana University School of Medicine, Indianapolis, Indiana, United States

4. Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, National Jewish Health, Denver, Colorado, United States

5. Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado, Aurora, Colorado, United States

6. Rocky Mountain Regional VA Medical Center, Aurora, Colorado, United States

Abstract

By exposing novel loss-of-function estrogen receptor alpha (Erα) mutant rats to a novel model of human high-altitude exposure, we demonstrate that ERα has subtle but inconsistent effects on endpoints relevant to cardiopulmonary adaptation to chronic hypoxia. Given that we observed some histologic, sex, and genotype differences, further research into cell-specific effects of ERα during hypoxia-induced cardiopulmonary adaptation is warranted.

Funder

Borstein Family Foundation

HHS | NIH | NHLBI | Division of Intramural Research

HHS | National Institutes of Health

Indiana Clinical and Translational Sciences Institute

U.S. Department of Veterans Affairs

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajplung.00161.2023

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