BATF2 enhances proinflammatory cytokine responses in macrophages and improves early host defense against pulmonary <i>Klebsiella pneumoniae</i> infection-Reference-Cited by-同舟云学术

BATF2 enhances proinflammatory cytokine responses in macrophages and improves early host defense against pulmonary Klebsiella pneumoniae infection

Published:2023-11-01 Issue:5 Volume:325 Page:L604-L616
ISSN:1040-0605
Container-title:American Journal of Physiology-Lung Cellular and Molecular Physiology
language:en
Short-container-title:American Journal of Physiology-Lung Cellular and Molecular Physiology

Author:

van der Geest Rick¹^ORCID,Peñaloza Hernán F.¹^ORCID,Xiong Zeyu¹,Gonzalez-Ferrer Shekina¹,An Xiaojing¹,Li Huihua¹,Fan Hongye¹,Tabary Mohammadreza¹,Nouraie S. Mehdi¹,Zhao Yanwu¹,Zhang Yingze¹^ORCID,Chen Kong¹,Alder Jonathan K.¹^ORCID,Bain William G.¹²^ORCID,Lee Janet S.¹³⁴⁵^ORCID

Affiliation:

1. Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States

2. Veterans Affairs Pittsburgh Health Care System, Pittsburgh, Pennsylvania, United States

3. Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, United States

4. Acute Lung Injury Center of Excellence, Department of Medicine, Pittsburgh, Pennsylvania, United States

5. Division of Pulmonary and Critical Care Medicine, John T. Milliken Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States

Abstract

This study investigates the signaling pathways that mediate induction of BATF2 expression downstream of TLR4 and also the impact of BATF2 on the host defense against pulmonary Kp infection. We demonstrate that Kp-induced upregulation of BATF2 in macrophages requires TRIF and type I IFN signaling. We also show that BATF2 enhances Kp-induced macrophage cytokine responses and that BATF2 contributes to the early host defense against pulmonary Kp infection.

Funder

HHS | NIH | National Heart, Lung, and Blood Institute

U.S. Department of Veterans Affairs

Publisher

American Physiological Society

Subject

Cell Biology,Physiology (medical),Pulmonary and Respiratory Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajplung.00441.2022

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