MicroRNA-200b deficiency is not sufficient to increase susceptibility to allergen-induced airway inflammation and dysfunction in mice-Reference-Cited by-同舟云学术

MicroRNA-200b deficiency is not sufficient to increase susceptibility to allergen-induced airway inflammation and dysfunction in mice

Published:2023-07-01 Issue:1 Volume:325 Page:L45-L53
ISSN:1040-0605
Container-title:American Journal of Physiology-Lung Cellular and Molecular Physiology
language:en
Short-container-title:American Journal of Physiology-Lung Cellular and Molecular Physiology

Author:

Kahnamoui Shana¹²,Basu Sujata¹²,Lei Yubin¹²,Patel Daywin¹²³,Keijzer Richard¹²³^ORCID,Pascoe Christopher D.¹²^ORCID

Affiliation:

1. Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, Manitoba, Canada

2. Biology of Breathing Group, The Children’s Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, Manitoba, Canada

3. Division of Pediatric Surgery and Pediatrics & Child Health, Department of Surgery, University of Manitoba, Winnipeg, Manitoba, Canada

Abstract

MicroRNA-200b regulates the abundance of key asthma-related genes. However, loss of miR-200b does not potentiate allergic asthma in a mouse model, suggesting that miR-200b deficiency may not be sufficient to drive of asthma pathogenesis.

Funder

The Children's Hospital Foundation of Manitoba | Children's Hospital Research Institute of Manitoba

Publisher

American Physiological Society

Subject

Cell Biology,Physiology (medical),Pulmonary and Respiratory Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajplung.00435.2022

Reference37 articles.

1. Asthma

2. Spotlight on microRNAs in allergy and asthma

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4. A Network of Sputum MicroRNAs Is Associated with Neutrophilic Airway Inflammation in Asthma

5. Airway Smooth Muscle Hyperproliferation is Regulated by microRNA-221 in Severe Asthma

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