Sex-specific lung inflammation and mitochondrial damage in a model of electronic cigarette exposure in asthma-Reference-Cited by-同舟云学术

Sex-specific lung inflammation and mitochondrial damage in a model of electronic cigarette exposure in asthma

Published:2023-11-01 Issue:5 Volume:325 Page:L568-L579
ISSN:1040-0605
Container-title:American Journal of Physiology-Lung Cellular and Molecular Physiology
language:en
Short-container-title:American Journal of Physiology-Lung Cellular and Molecular Physiology

Author:

Song Min-Ae¹,Kim Ji Young²^ORCID,Gorr Matthew W.³^ORCID,Miller Roy A.³,Karpurapu Manjula⁴,Nguyen Jackie⁴,Patel Devki¹,Archer Kellie J.⁵,Pabla Navjot²,Shields Peter G.⁶^ORCID,Wold Loren E.³^ORCID,Christman John W.⁴^ORCID,Chung Sangwoon⁴^ORCID

Affiliation:

1. Division of Environmental Health Sciences, College of Public Health, The Ohio State University, Columbus, Ohio, United States

2. Division of Pharmaceutics and Pharmacology, College of Pharmacy and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, United States

3. Division of Cardiac Surgery, Department of Surgery, College of Medicine, The Ohio State University, Columbus, Ohio, United States

4. Division of Pulmonary, Critical Care and Sleep Medicine, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, United States

5. Division of Biostatistics, College of Public Health, The Ohio State University, Columbus, Ohio, United States

6. Comprehensive Cancer Center, The Ohio State University and James Cancer Hospital, Columbus, Ohio, United States

Abstract

Respiratory immunity is dysregulated in preexisting asthma, and further perturbations by EC use could exacerbate asthma severity. However, the extent of their toxicity and the involved mechanisms contributing to the deleterious impact of EC exposure on patients with preexisting asthma have not been delineated. We found that EC has unique biological impacts in lungs and potential sex differences with loss of TFAM, a key mtDNA regulator, in lung epithelial region from our animal EC study.

Funder

Internal Medicine at the Ohio State University

Research start-up from OSU Comprehensive Cancer Center

OSU College of Public Health

American Heart Association

American Lung Association

HHS | NIH | National Cancer Institute

HHS | NIH | National Heart, Lung, and Blood Institute

Publisher

American Physiological Society

Subject

Cell Biology,Physiology (medical),Pulmonary and Respiratory Medicine,Physiology