Investigating the role of platelets and platelet-derived transforming growth factor-β in idiopathic pulmonary fibrosis-Reference-Cited by-同舟云学术

Investigating the role of platelets and platelet-derived transforming growth factor-β in idiopathic pulmonary fibrosis

Published:2023-10-01 Issue:4 Volume:325 Page:L487-L499
ISSN:1040-0605
Container-title:American Journal of Physiology-Lung Cellular and Molecular Physiology
language:en
Short-container-title:American Journal of Physiology-Lung Cellular and Molecular Physiology

Author:

Chong Deborah L. W.¹²^ORCID,Mikolasch Theresia A.¹^ORCID,Sahota Jagdeep¹,Rebeyrol Carine¹,Garthwaite Helen S.¹,Booth Helen L.³,Heightman Melissa³,Denneny Emma K.¹^ORCID,José Ricardo J.¹,Khawaja Akif A.¹,Duckworth Anna⁴^ORCID,Labelle Myriam⁵^ORCID,Scotton Chris J.¹⁴^ORCID,Porter Joanna C.¹

Affiliation:

1. UCL Respiratory, Division of Medicine, University College London, London, United Kingdom

2. Institute for Infection and Immunity, St George’s University of London, London, United Kingdom

3. Interstitial Lung Disease Service, University College London Hospital, London, United Kingdom

4. Department of Clinical and Biomedical Science, University of Exeter, Exeter, United Kingdom

5. Department of Developmental Neurobiology, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States

Abstract

Platelets are a rich source of profibrotic TGFβ; however, the role of platelets in idiopathic pulmonary fibrosis (IPF) is unclear. We identified that patients with IPF have significantly more platelets, neutrophils, and active TGFβ in their airways than control patients. Using an animal model of IPF, we demonstrated that platelet-derived TGFβ does not significantly drive lung fibrosis or inflammation. Our findings offer a better understanding of platelets in both human and animal studies of IPF.

Funder

European Commission

NIHR | University College London Hospitals Biomedical Research Centre

UKRI | Medical Research Council

Publisher

American Physiological Society

Subject

Cell Biology,Physiology (medical),Pulmonary and Respiratory Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajplung.00227.2022

Reference57 articles.

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5. Forced Vital Capacity in Idiopathic Pulmonary Fibrosis — FDA Review of Pirfenidone and Nintedanib

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