Natural antibodies targeting LPS in pleural effusions of various etiologies

Author:

Sarrigeorgiou Ioannis1,Rouka Erasmia2ORCID,Kotsiou Ourania S.2,Perlepe Garyfallia3,Gerovasileiou Efrosini S.4,Gourgoulianis Konstantinos I.3,Lymberi Peggy1,Zarogiannis Sotirios G.4ORCID

Affiliation:

1. Laboratory of Immunology, Department of Immunology, Hellenic Pasteur Institute, Athens, Greece

2. Department of Nursing, School of Health Sciences, University of Thessaly, Larissa, Greece

3. Department of Respiratory Medicine, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece

4. Department of Physiology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece

Abstract

Here we describe the detection and quantification of natural antibodies (NAbs) in the human pleural cavity. We show for the first time that IgM, IgG, and IgA anti-LPS natural antibodies are detected and measured in pleural effusions of infectious, noninfectious, and malignant etiologies and provide clinical correlates to demonstrate the translational impact of our findings.

Publisher

American Physiological Society

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