The hemodynamic interplay between pulmonary ischemia-reperfusion injury and right ventricular function in lung transplantation: a translational porcine model-Reference-Cited by-同舟云学术

The hemodynamic interplay between pulmonary ischemia-reperfusion injury and right ventricular function in lung transplantation: a translational porcine model

Published:2023-11-01 Issue:5 Volume:325 Page:L675-L688
ISSN:1040-0605
Container-title:American Journal of Physiology-Lung Cellular and Molecular Physiology
language:en
Short-container-title:American Journal of Physiology-Lung Cellular and Molecular Physiology

Author:

Orlitová Michaela¹²^ORCID,Verbelen Tom¹³^ORCID,Frick Anna E.¹⁴^ORCID,Vanstapel Arno⁵⁶^ORCID,Van Beersel Dieter¹⁷^ORCID,Ordies Sofie¹⁷^ORCID,Van Slambrouck Jan²⁶^ORCID,Kaes Janne⁶^ORCID,Jin Xin⁶^ORCID,Coudyzer Walter⁸^ORCID,Verleden Stijn E.⁹^ORCID,Verleden Geert M.⁶¹⁰^ORCID,Vanaudenaerde Bart M.⁶^ORCID,Van Raemdonck Dirk E.²⁶^ORCID,Vos Robin⁶¹⁰^ORCID,Ceulemans Laurens J.²⁶^ORCID,Claus Piet¹^ORCID,Neyrinck Arne P.¹⁷^ORCID

Affiliation:

1. Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium

2. Department of Thoracic Surgery, University Hospitals Leuven, Leuven, Belgium

3. Department of Cardiac Surgery, University Hospitals Leuven, Leuven, Belgium

4. Department of Thoracic Surgery, Medical University of Vienna, Vienna, Austria

5. Department of Pathology, University Hospitals Leuven, Leuven, Belgium

6. Laboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium

7. Department of Anesthesiology, University Hospitals Leuven, Leuven, Belgium

8. Department of Radiology, University Hospitals Leuven, Leuven, Belgium

9. Antwerp Surgical Training, Anatomy and Research Center, University of Antwerp, Antwerp, Belgium

10. Department of Respiratory Diseases, University Hospitals Leuven, Leuven, Belgium

Abstract

In contrast to the abundant literature of mechanical pulmonary artery clamping to increase right ventricular afterload, we developed a model adding a biological factor of pulmonary ischemia-reperfusion injury. We did not only focus on the right ventricular behavior, but also on the interaction with the injured lung. We are the first to describe this interaction while addressing the hemodynamic intraoperative phases of clinical lung transplantation.

Funder

KU Leuven

Publisher

American Physiological Society

Subject

Cell Biology,Physiology (medical),Pulmonary and Respiratory Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajplung.00281.2022

Reference38 articles.

1. Primary Graft Dysfunction and Long-term Pulmonary Function After Lung Transplantation

2. Protein biomarkers associated with primary graft dysfunction following lung transplantation

3. Lung ischemia-reperfusion injury: a molecular and clinical view on a complex pathophysiological process

4. Ischemia–Reperfusion–induced Lung Injury

5. A Focused Review on Primary Graft Dysfunction after Clinical Lung Transplantation: A Multilevel Syndrome

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