DEAD-box helicase 54 regulates microglial inflammatory response in rats with chronic constriction injuries through NF-κB/NLRP3 signaling axis-Reference-Cited by-全球学者库

DEAD-box helicase 54 regulates microglial inflammatory response in rats with chronic constriction injuries through NF-κB/NLRP3 signaling axis

Published:2023-08-01 Issue:2 Volume:130 Page:392-400
ISSN:0022-3077
Container-title:Journal of Neurophysiology
language:en
Short-container-title:Journal of Neurophysiology

Author:

Liu Panmei¹,Zhang Yu²,Li Xinxin¹,Ma Minyu¹^ORCID

Affiliation:

1. Department of Pain Management, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China

2. Department of Anesthesiology, the Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China

Abstract

The role of DDX54 protein in LPS-induced microglia and a chronic constriction injury (CCI) rat model was investigated for the first time. DDX54 interference can inhibit microglial activation and reduce the secretion of inflammatory factors. The interaction between DDX54 protein and MYD88 mRNA was explored for the first time. DDX54 promotes NF-κB/NLRP3 signaling activation by regulating MYD88 transcription in a CCI rat model.

Publisher

American Physiological Society

Subject

Physiology,General Neuroscience

Link

https://journals.physiology.org/doi/pdf/10.1152/jn.00411.2022

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