<i>Kcnma1</i> alternative splicing in mouse kidney: regulation during development and by dietary K<sup>+</sup> intake-Reference-Cited by-同舟云学术

Kcnma1 alternative splicing in mouse kidney: regulation during development and by dietary K⁺ intake

Published:2024-07-01 Issue:1 Volume:327 Page:F49-F60
ISSN:1931-857X
Container-title:American Journal of Physiology-Renal Physiology
language:en
Short-container-title:American Journal of Physiology-Renal Physiology

Author:

Whelan Sarah Christine M.¹^ORCID,Mutchler Stephanie M.¹^ORCID,Han Agnes¹,Priestley Catherine¹,Satlin Lisa M.²^ORCID,Kleyman Thomas R.¹³⁴^ORCID,Shi Shujie¹^ORCID

Affiliation:

1. Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States

2. Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, New York, United States

3. Department of Cell Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States

4. Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States

Abstract

We identified the major Kcnma1 splice variants that are specifically expressed in the whole mouse kidney or aldosterone-sensitive distal nephron segments. Our data suggest that Kcnma1 alternative splicing is developmentally regulated and subject to changes in dietary K+.

Funder

HHS | NIH | National Heart, Lung, and Blood Institute

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajprenal.00100.2024

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