Affiliation:
1. Renal-Electrolyte Division, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States
Abstract
Receptor-associated protein inhibits binding and uptake of all known endogenous ligands by megalin and cubilin receptors via unknown mechanism(s). Here, we took advantage of recently generated knockout cell lines to dissect the effect of this protein on megalin- and cubilin-mediated endocytosis. Our study reveals a novel role for receptor-associated protein in blocking megalin-stimulated endocytic uptake of fluid-phase markers and receptor-bound ligands in proximal tubule cells in addition to its direct effect on ligand binding to megalin receptors.
Funder
Aktis Oncology
HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases
HHS | NIH | NIH Office of the Director
HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases
Publisher
American Physiological Society
Cited by
1 articles.
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