Bone marrow stromal cell antigen-1 deficiency protects from acute kidney injury-Reference-Cited by-同舟云学术

Bone marrow stromal cell antigen-1 deficiency protects from acute kidney injury

Published:2024-02-01 Issue:2 Volume:326 Page:F167-F177
ISSN:1931-857X
Container-title:American Journal of Physiology-Renal Physiology
language:en
Short-container-title:American Journal of Physiology-Renal Physiology

Author:

Inoue Tsuyoshi¹²^ORCID,Umene Ryusuke²³,Sung Sun-Sang J.¹^ORCID,Tanaka Shinji¹,Huang Liping¹,Yao Junlan¹,Hashimoto Noritatsu²,Wu Chia-Hsien²,Nakamura Yasuna²^ORCID,Nishino Tomoya³,Ye Hong¹,Rosin Diane L.⁴^ORCID,Ishihara Katsuhiko⁵^ORCID,Okusa Mark D.¹^ORCID

Affiliation:

1. Division of Nephrology, Center for Immunity, Inflammation, and Regenerative Medicine, University of Virginia, Charlottesville, Virginia, United States

2. Department of Physiology of Visceral Function and Body Fluid, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan

3. Department of Nephrology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan

4. Department of Pharmacology, University of Virginia, Charlottesville, Virginia, United States

5. Department of Design for Medical and Health Care, Faculty of Health and Welfare Services Administration, Kawasaki University of Medical Welfare, Okayama, Japan

Abstract

Acute kidney injury (AKI), a serious disease for which there is no effective Federal Drug Administration-approved treatment, is associated with high mortality rates. Bone marrow stromal cell antigen-1 (Bst1) is a cell surface molecule that can cause kidney fibrosis, but its role in AKI is largely unknown. Our study showed that Bst1−/− mice revealed a protective effect against renal bilateral ischemia-reperfusion injury (IRI). Adoptive transfer studies confirmed that Bst1 expression in hematopoietic cells, especially neutrophils, contributed to renal bilateral IRI.

Funder

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

MEXT | Japan Society for the Promotion of Science

Japan Agency for Medical Research and Development

MEXT | JST | Fusion Oriented REsearch for disruptive Science and Technology

Publisher

American Physiological Society

Subject

Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajprenal.00175.2023

Reference36 articles.

1. AKI!Now Initiative: Recommendations for Awareness, Recognition, and Management of AKI

2. Immune cells and inflammation in AKI to CKD progression

3. Role of Immune Cells in Acute Kidney Injury and Repair

4. BST-1, a surface molecule of bone marrow stromal cell lines that facilitates pre-B-cell growth.

5. Evolution and Function of the ADP Ribosyl Cyclase/CD38 Gene Family in Physiology and Pathology

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Beast of (renal) burden? Bst1-expressing neutrophils in kidney injury;American Journal of Physiology-Renal Physiology;2024-02-01