Podocyte injury at young age causes premature senescence and worsens glomerular aging-Reference-Cited by-同舟云学术

Podocyte injury at young age causes premature senescence and worsens glomerular aging

Published:2024-01-01 Issue:1 Volume:326 Page:F120-F134
ISSN:1931-857X
Container-title:American Journal of Physiology-Renal Physiology
language:en
Short-container-title:American Journal of Physiology-Renal Physiology

Author:

Veloso Pereira Beatriz Maria¹²,Zeng Yuting³^ORCID,Maggiore Joseph C.⁴^ORCID,Schweickart Robert Allen⁵^ORCID,Eng Diana G.¹^ORCID,Kaverina Natalya¹^ORCID,McKinzie Sierra R.¹,Chang Anthony⁶^ORCID,Loretz Carol J.¹,Thieme Karina²^ORCID,Hukriede Neil A.⁴,Pippin Jeffrey W.¹^ORCID,Wessely Oliver⁵^ORCID,Shankland Stuart J.¹⁷^ORCID

Affiliation:

1. Division of Nephrology, University of Washington, Seattle, Washington, United States

2. Department of Physiology and Biophysics, University of São Paulo, São Paulo, Brazil

3. Department of Chemistry, University of Washington, Seattle, Washington, United States

4. Department of Developmental Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States

5. Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, United States

6. Department of Pathology, University of Chicago, Chicago, Illinois, United States

7. Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington, United States

Abstract

Glomerular function is decreased by aging. However, little is known about the molecular mechanisms involved in age-related glomerular changes and which factors could contribute to a worse glomerular aging process. Here, we reported that podocyte injury in young mice and culture podocytes induced senescence, a marker of aging, and accelerates glomerular aging when compared with healthy aging mice.

Funder

Fundação de Amparo à Pesquisa do Estado de São Paulo

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

U.S. Department of Defense

University of Pittsburgh

Publisher

American Physiological Society

Subject

Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajprenal.00261.2023

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1. Injury in nonaged podocytes as an accelerator of glomerular aging;American Journal of Physiology-Renal Physiology;2024-01-01