Effects of reactive oxygen species on renal tubular transport

Author:

Gonzalez-Vicente Agustin1ORCID,Hong Nancy2,Garvin Jeffrey L.2

Affiliation:

1. Department of Inflammation and Immunity, Cleveland Clinic, Lerner Research Institute, Cleveland, Ohio

2. Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University Cleveland, Ohio

Abstract

Reactive oxygen species (ROS) play a critical role in regulating nephron transport both via transcellular and paracellular pathways under physiological and pathological circumstances. Here, we review the progress made in the past ~10 yr in understanding how ROS regulate solute and water transport in individual nephron segments. Our knowledge in this field is still rudimentary, with basic information lacking. This is most obvious when looking at the reported disparate effects of superoxide ([Formula: see text]) and H2O2 on proximal nephron transport, where there are no easy explanations as to how to reconcile the data. Similarly, we know almost nothing about the regulation of transport in thin descending and ascending limbs, information that is likely critical to understanding the urine concentrating mechanism. In the thick ascending limb, there is general agreement that ROS enhance transcellular reabsorption of NaCl, but we know very little about their effects on the paracellular pathway and therefore Ca2+ and Mg2+ transport. In the distal convoluted tubule, precious little is known. In the collecting duct, there is general agreement that ROS stimulate the epithelial Na+ channel.

Funder

HSS/NIH/National Heart Lung and Blood Institute

HSS/NIH/National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Physiological Society

Subject

Physiology

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