Renal tubular SGK1 is required to achieve blood pressure surge and circadian rhythm

Author:

Staub Olivier1ORCID,Debonneville Anne1ORCID,Stifanelli Matteo1,Juffre Alexandria23,Maillard Marc P.4ORCID,Gumz Michelle L.23ORCID,Al-Qusairi Lama15ORCID

Affiliation:

1. Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland

2. Division of Nephrology, Department of Physiology and Aging, College of Medicine, University of Florida, Gainesville, Florida, United States

3. Center for Integrative Cardiovascular and Metabolic Diseases, University of Florida, Gainesville, Florida, United States

4. Division of Nephrology, Lausanne University Hospital, Lausanne, Switzerland

5. Division of Nephrology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States

Abstract

Dysregulation of blood pressure (BP) circadian rhythm is associated with metabolic, cardiovascular, and kidney diseases. Our study provides experimental evidence demonstrating, for the first time, that renal tubule serum- and glucocorticoid-induced kinase 1 ( SGK1) plays an essential role in inducing the BP surge. Inhibitors and activators of SGK1 signaling are parts of several therapeutic strategies. Our findings highlight the importance of the drug intake timing to be in phase with SGK1 function to avoid dysregulation of BP circadian rhythm.

Funder

Fondation Leducq

HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases

Pitt | Pittsburgh Center for Kidney Research, University of Pittsburgh

SNF | Swiss National Centre of Competence in Research Kidney Control of Homeostasis

Publisher

American Physiological Society

Subject

Physiology

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