Urine concentration impairment in sickle cell anemia: genuine nephrogenic diabetes insipidus or osmotic diuresis?-Reference-Cited by-同舟云学术

Urine concentration impairment in sickle cell anemia: genuine nephrogenic diabetes insipidus or osmotic diuresis?

Published:2024-02-01 Issue:2 Volume:326 Page:F278-F284
ISSN:1931-857X
Container-title:American Journal of Physiology-Renal Physiology
language:en
Short-container-title:American Journal of Physiology-Renal Physiology

Author:

de Berny Quentin¹^ORCID,Saint-Jacques Camille²,Santin Aline³^ORCID,Mattioni Sarah³,Steichen Olivier³^ORCID,Chieze Rémi²,Frochot Vincent²,Letavernier Emmanuel²^ORCID,Lionnet François³,Haymann Jean-Philippe²^ORCID

Affiliation:

1. Service de Néphrologie, Dialyse et Transplantation Rénale, Centre Hospitalier Universitaire d’Amiens, Amiens, France

2. Service d'Explorations Fonctionnelles Multidisciplinaires, Hôpital Tenon, Assistance Publique-Hôpitaux de Paris, UMR-S 1155, Médecine Sorbonne Université, Paris, France

3. Service de Médecine Interne, Hôpital Tenon, Assistance Publique Hôpitaux de Paris, Médecine Sorbonne Université, Paris, France

Abstract

The urine concentration impairment in sickle cell anemia is an osmotic diuresis related to an impaired renal medullary gradient leading to an ADH plateau effect. The fasting plasma ADH was high in the context of a basic state of close-to-maximal urine concentration probably driven by short nephrons maintaining a cortex-outer medullary gradient (about 400 milliosmoles). The patients had a low daily osmoles intake without evidence of thirst dysregulation so no one experienced polyuria.

Publisher

American Physiological Society

Subject

Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajprenal.00313.2023

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