Secretin, at the hub of water-salt homeostasis

Author:

Bai Jenny Juan1,Tan Chong Da1,Chow Billy K. C.1

Affiliation:

1. School of Biological Sciences, University of Hong Kong, Hong Kong, China

Abstract

Water and salt metabolism are tightly regulated processes. Maintaining this milieu intérieur within narrow limits is critical for normal physiological processes to take place. Disturbances to this balance can result in disease and even death. Some of the better-characterized regulators of water and salt homeostasis include angiotensin II, aldosterone, arginine vasopressin, and oxytocin. Although secretin (SCT) was first described >100 years ago, little is known about the role of this classic gastrointestinal hormone in the maintenance of water-salt homeostasis. In recent years, increasing body of evidence suggested that SCT and its receptor play important roles in the central nervous system and kidney to ensure that the mammalian extracellular fluid osmolarity is kept within a healthy range. In this review, we focus on recent advances in our understanding of the molecular, cellular, and network mechanisms by which SCT and its receptor mediate the control of osmotic homeostasis. Implications of hormonal cross talk and receptor-receptor interaction are highlighted.

Funder

Hong Kong Government RGC Grant GRF

Hong Kong Government RGC Grant CRF

Publisher

American Physiological Society

Subject

Physiology

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