Affiliation:
1. Translational Medicine Centre, Jiangxi University of Chinese Medicine, Nanchang, People’s Republic of China
2. Center for Metabolic Disease Research and Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania, United States
Abstract
Autophagy exhibits a double-edged effect on cell survival and plays an essential role in renal pathophysiology. We for the first time reported a novel function of autophagy that controls the urine-concentrating capability in physiological conditions. We found that water deprivation (WD) differentially regulated autophagy in the kidneys of mice in a time-dependent manner and autophagy regulates the urine-concentrating capability mainly by regulating AQP2/V2R and ACE/ANG II signaling in the renal cortex in WD mice.
Funder
NSFC | National Natural Science Foundation of China
Jiangxi Provincial Natural Science Foundation
Jiangxi “Double Thousand Plan”
Ph.D. Start-up Research Fund in Jiangxi University of Chinese Medicine
science and technology research project in Education Department of Jiangxi Province
science and technology research project in Health Commission of Jiangxi Province
Jiangxi Key Laboratory grant in Science and Technology Department of Jiangxi Province
Scientific and Technological Innovation Team grant of the Jiangxi University of Chinese Medicine
Publisher
American Physiological Society
Cited by
1 articles.
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