Gene–exercise interaction on brain health in children with overweight/obesity: the ActiveBrains randomized controlled trial

Author:

Plaza-Florido Abel12ORCID,Esteban-Cornejo Irene134,Mora-Gonzalez Jose1,Torres-Lopez Lucia V.1,Osuna-Prieto Francisco J.15,Gil-Cosano Jose J.16,Radom-Aizik Shlomit2ORCID,Labayen Idoia3789ORCID,Ruiz Jonatan R.134,Altmäe Signe41011,Ortega Francisco B.1312

Affiliation:

1. Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain

2. Pediatric Exercise and Genomics Research Center, Department of Pediatrics, School of Medicine, University of California at Irvine, Irvine, California, United States

3. CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Granada, Spain

4. Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain

5. Instituto de Investigación Sanitaria Pere Virgili, University Hospital of Tarragona Joan XXIII, Tarragona, Spain

6. Department of Communication and Education, Universidad Loyola Andalucía, Dos Hermanas, Sevilla, Spain

7. Research Institute for Sustainability & Food Chain Innovation (IS-FOOD), Public University of Navarre, Pamplona, Spain

8. Department of Health Sciences, Public University of Navarre, Pamplona, Spain

9. IdiSNA, Navarra Institute for Health Research, Pamplona, Spain

10. Department of Biochemistry and Molecular Biology, Faculty of Sciences, University of Granada, Granada, Spain

11. Division of Obstetrics and Gynecology, Department of Clinical Scinece, Intervention and Technology (CLINTEC), Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden

12. Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland

Abstract

Interindividual differences have been reported in brain health-related outcomes in response to exercise interventions in adults, which could be partially explained by genetic background differences. However, the role of genetic polymorphisms on brain health-related outcomes in response to exercise interventions remains unexplored in pediatric population. The current study in children with overweight/obesity showed that a genetic score composed of six brain health-related polymorphisms ( BDNF, CREB1, NTRK2, COMT, and APOE) regulated the exercise-induced response on several brain health outcomes, yet mainly and more consistently on cognitive flexibility.

Funder

EXERNET Research Network on Exercise and Health

Pediatric Exercise and Genomics Research Center

Spanish Ministry of Economy and Competitiveness

Spanish Ministry of Science and Innovation

Maragrita Salas program

Consejería de Economía, Innovación, Ciencia y Empleo, Junta de Andalucía

EC | European Regional Development Fund

HHS | National Institutes of Health

Ministerio de Ciencia e Innovación

Ministry of Economy and Competitiveness | Instituto de Salud Carlos III

Universidad de Granada

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

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