The role of TFE3 in mediating skeletal muscle mitochondrial adaptations to exercise training-Reference-Cited by-同舟云学术

The role of TFE3 in mediating skeletal muscle mitochondrial adaptations to exercise training

Published:2024-02-01 Issue:2 Volume:136 Page:262-273
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Wong Jenna C.¹,Oliveira Ashley N.¹,Khemraj Priyanka¹,Hood David A.¹^ORCID

Affiliation:

1. Muscle Health Research Centre, School of Kinesiology and Health Science, York University, Toronto, Ontario, Canada

Abstract

Our understanding of the role of transcription factor E3 (TFE3) in skeletal muscle is very limited. This research shows that TFE3 plays a direct role in skeletal muscle mitochondrial enhancement with exercise training, thereby introducing a paradigm shift in our perception of the function of TFE3 in mitochondrial maintenance, beyond mitophagy. This research serves to introduce TFE3 as a protein that holds promise as a future therapeutic target for metabolic diseases and skeletal muscle dysfunction.

Funder

Canada Research Chairs

Gouvernement du Canada | IRSC | CIHR Skin Research Training Centre

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00484.2023

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