Cortical microglia dynamics are conserved during voluntary wheel running-Reference-Cited by-全球学者库

Cortical microglia dynamics are conserved during voluntary wheel running

Published:2024-01-01 Issue:1 Volume:136 Page:89-108
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Strohm Alexandra O.¹^ORCID,O’Connor Thomas N.²³,Oldfield Sadie⁴,Young Sala⁴,Hammond Christian⁵,McCall Matthew⁵^ORCID,Dirksen Robert T.³,Majewska Ania K.⁴⁶^ORCID

Affiliation:

1. Department of Environmental Medicine, University of Rochester Medical Center, Rochester, New York, United States

2. Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, New York, United States

3. Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York, United States

4. Department of Neuroscience, University of Rochester Medical Center, Rochester, New York, United States

5. Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, New York, United States

6. Center for Visual Science, University of Rochester Medical Center, Rochester, New York, United States

Abstract

We demonstrate the first use of chronic in vivo imaging of microglia over time during physical exercise. We found that microglia movement, morphology, and process motility were remarkably stable during voluntary wheel running (VWR). Additionally, microglia in running mice respond similarly to laser ablation injury compared to sedentary mice. These findings indicate that VWR does not induce changes in microglia dynamics in healthy adults. Exercise may elicit positive effects on the brain through other mechanisms.

Funder

HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases

HHS | NIH | National Institute of Environmental Health Sciences

HHS | NIH | National Institute of Neurological Disorders and Stroke

HHS | NIH | National Institute on Alcohol Abuse and Alcoholism

UR | Medical Center, University of Rochester

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00311.2023

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