Vancomycin modestly attenuates symptom severity during onset of and recovery from exertional heat stroke in mice-Reference-Cited by-同舟云学术

Vancomycin modestly attenuates symptom severity during onset of and recovery from exertional heat stroke in mice

Published:2023-12-01 Issue:6 Volume:135 Page:1348-1359
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Oki Kentaro¹^ORCID,Ward Jermaine A.¹,Ward Shauna M.¹,Plamper Mark L.¹,Henderson Chloe G.¹²,Mayer Thomas A.¹,Caldwell Aaron R.¹²^ORCID,Leon Lisa R.¹

Affiliation:

1. Thermal and Mountain Medicine Division, United States Army Research Institute of Environmental Medicine, Natick, Massachusetts, United States

2. Oak Ridge Institute of Science and Education, Oak Ridge, Tennessee, United States

Abstract

Vancomycin prophylaxis lowered core temperature before and during EHS, mitigated EHS-associated rise of hepatic biomarkers and cytokines/chemokines in circulation (particularly at 24 h), and corresponded to inhibited phosphorylation of hepatic c-Jun NH2-terminal kinase on Threonine 183/Tyrosine 185 at 0 and 3 h in conscious, unanesthetized mice. However, vancomycin also induced cecal enlargement suggesting its off-target effects could limit its utility against EHS.

Funder

Military Operational Medicine Research Program

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00368.2023

Reference53 articles.

1. Heat Stroke

2. National Athletic Trainers' Association Position Statement: Exertional Heat Illnesses

3. Characterizing occupational heat-related mortality in the United States, 2000-2010: An analysis using the census of fatal occupational injuries database